Summer 2000
| Title | Opening | Closing | Gross | Theaters | 1st Wk % | Per Scrn | Distributor | |||||
| Total | Opening | Opening | Widest | |||||||||
| (May 5 - Aug 31) | ||||||||||||
| 1 | Mission: Impossible 2 | 05-24-00 | 10-19-00 | * | 215,397,307 | 70,816,215 | 3653 | 3669 | 32.88 | 58,707 | Paramount | |
| 2 | Gladiator | 05-05-00 | 10-19-00 | 186,610,052 | 34,819,017 | 2938 | 3188 | 18.66 | 58,535 | DreamWorks | ||
| 3 | Perfect Storm, The | 06-30-00 | 12-07-00 | 182,605,083 | 41,325,042 | 3407 | 3407 | 22.63 | 53,597 | Warner Bros. | ||
| 4 | X-Men | 07-14-00 | 11-23-00 | 157,299,718 | 54,471,475 | 3025 | 3112 | 34.63 | 50,546 | Fox | ||
| 5 | Scary Movie | 07-07-00 | 11-23-00 | 156,997,084 | 42,346,669 | 2912 | 3301 | 26.97 | 47,560 | Miramax | ||
| 6 | What Lies Beneath | 07-21-00 | 01-04-01 | 155,385,184 | 29,702,959 | 2577 | 2925 | 19.12 | 53,123 | DreamWorks | ||
| 7 | Dinosaur | 05-19-00 | 01-04-01 | 137,748,063 | 38,854,851 | 3257 | 3319 | 28.21 | 41,503 | Buena Vista | ||
| 8 | Nutty Professor II : The Klumps | 07-28-00 | 01-04-01 | 123,307,945 | 42,518,830 | 3242 | 3251 | 34.48 | 37,929 | Universal | ||
| 9 | Big Momma's House | 06-02-00 | 11-23-00 | 117,559,438 | 25,661,041 | 2802 | 2854 | 21.83 | 41,191 | Fox | ||
| 10 | Patriot, The | 06-28-00 | 10-19-00 | 113,302,500 | 22,413,710 | 3061 | 3061 | 19.78 | 37,015 | Sony | ||
| 11 | Chicken Run | 06-21-00 | 11-02-00 | 106,834,564 | 17,506,162 | 2491 | 2901 | 16.39 | 36,827 | DreamWorks | ||
| 12 | Gone in 60 Seconds | 06-09-00 | 11-30-00 | 101,643,008 | 25,336,048 | 3006 | 3089 | 24.93 | 32,905 | Buena Vista | ||
| 13 | Me, Myself, and Irene | 06-23-00 | 11-09-00 | 90,567,722 | 24,209,385 | 3019 | 3087 | 26.73 | 29,338 | Fox | ||
| 14 | Space Cowboys | 08-04-00 | 01-18-01 | 90,454,043 | 18,093,776 | 2805 | 2835 | 20.00 | 31,906 | Warner Bros. | ||
| 15 | Hollow Man | 08-04-00 | 11-23-00 | 73,209,340 | 26,414,386 | 2956 | 2956 | 36.08 | 24,766 | Sony | ||
| 16 | Shaft | 06-16-00 | 10-05-00 | 70,257,528 | 21,714,757 | 2337 | 2433 | 30.91 | 28,877 | Paramount | ||
| 17 | Kid, The | 07-07-00 | 11-30-00 | 69,688,384 | 12,687,726 | 2167 | 2343 | 18.21 | 29,743 | Buena Vista | ||
| 18 | Road Trip | 05-19-00 | 09-07-00 | 68,525,609 | 15,484,004 | 2530 | 2654 | 22.60 | 25,820 | DreamWorks | ||
| 19 | Bring It On | 08-25-00 | 01-04-01 | 68,379,000 | 17,362,105 | 2380 | 2466 | 25.39 | 27,729 | Universal | ||
| 20 | Cell, The | 08-18-00 | 12-14-00 | 61,301,011 | 17,515,050 | 2411 | 2476 | 28.57 | 24,758 | New Line | ||
| 21 | Coyote Ugly | 08-04-00 | 01-04-01 | 60,786,269 | 17,319,282 | 2653 | 2664 | 28.49 | 22,818 | Buena Vista | ||
| 22 | Shanghai Noon | 05-26-00 | 10-05-00 | * | 56,932,305 | 19,647,065 | 2711 | 2751 | 34.51 | 20,695 | Buena Vista | |
| 23 | Replacements, The | 08-11-00 | 10-26-00 | 44,331,833 | 11,039,214 | 2754 | 2754 | 24.90 | 16,097 | Warner Bros. | ||
| 24 | Pokémon the Movie 2000 | 07-21-00 | 10-12-00 | 43,746,923 | 19,575,608 | 2752 | 2752 | 44.75 | 15,896 | Warner Bros. | ||
| 25 | Original Kings of Comedy, The | 08-18-00 | 11-23-00 | 38,168,022 | 11,053,832 | 847 | 1082 | 28.96 | 35,275 | Paramount | ||
| 26 | Autumn in New York | 08-11-00 | 11-30-00 | 37,752,931 | 10,987,006 | 2255 | 2282 | 29.10 | 16,544 | MGM/UA | ||
| 27 | Art of War, The | 08-25-00 | 11-09-00 | 30,199,105 | 10,410,993 | 2630 | 2630 | 34.47 | 11,483 | Warner Bros. | ||
| 28 | Bless the Child | 08-11-00 | 11-09-00 | 29,374,178 | 9,413,684 | 2524 | 2524 | 32.05 | 11,638 | Paramount | ||
| 29 | Adventures of Rocky and Bullwinkle, The | 06-30-00 | 10-05-00 | 26,005,820 | 6,814,270 | 2460 | 2482 | 26.20 | 10,478 | Universal | ||
| 30 | Titan A.E. | 06-16-00 | 09-07-00 | 22,751,979 | 9,376,845 | 2734 | 2775 | 41.21 | 8,199 | Fox | ||
estimated final grosses in italics